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Top2

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Untangling the roles of TOP2A and TOP2B in transcription and cancer - AAAS. TOP2 poisons such as etoposide and doxorubicin form ternary complexes of TOP2 and DNA that trap TOP2 to 5′ termini of DNA DSBs and inhibit the religation of broken DNA strands (50, 51). Etoposide is a poor DNA intercalator; however, extensive interactions of etoposide with DNA are promoted and stabilized when a complex is formed with TOP2 ( 44 ).. Untangling the roles of TOP2A and TOP2B in transcription and cancer. Cellular localization, catalytic cycle, and evolutionary conservation of TOP2 enzymes. (A) TOP2A and TOP2B are detected in the nucleoplasm, nucleoli, and mitochondria in the cell.(B) Eukaryotic TOP2 binds helix-helix crossovers of DNA as a homodimer that cleaves both strands of duplex DNA with 5′-four base overhangs and forms the TOP2cc by covalently attaching the catalytic tyrosine (Tyr) to .. TOP2 | SGD - Saccharomyces Genome Database. DiNardo S, et al. (1984) DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proc Natl Acad Sci U S A 81 (9):2616-20 PMID: 6326134. SGD Paper. DOI full text.. 7153 - Gene ResultTOP2A DNA topoisomerase II alpha [ (human)]. The human TOP2 enzymes catalyze their reactions via formation of a reversible covalent enzyme DNA-protein crosslink, the TOP2 cleavage complex (TOP2cc)

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. [review] This conversion is dependent on proteasomal degradation and TDP2 phosphodiesterase activity. Quantitative modeling shows that only two features of pre-existing chromatin structure .. TOP2A Gene - GeneCards | DNA Topoisomerase II Alpha. TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene

top2

Diseases associated with TOP2A include Malignant Peripheral Nerve Sheath Tumor and Neuroblastoma . Among its related pathways are Transport of the SLBP independent Mature mRNA and Cell Cycle, Mitotic . Gene Ontology (GO) annotations related to this gene include RNA binding and protein .. A nucleotide resolution map of Top2-linked DNA breaks in the . - Nature. Topoisomerase 2 (Top2) is known to resolve DNA topological stress through double strand breaks (DSBs), yet Top2 inhibition has been reported to result in a significant amount of single-strand .. Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA . - Nature. This Top2 model, similar to our Top1 model 9, is supported by our recent findings showing that ATM deficiency 5,7, TRF2 uncapping 6, and telomere targeting 8 promote telomeric DNA damage and T .. DNA topoisomerase II and its growing repertoire of biological . - Nature

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. This paper is important in understanding TOP2 checkpoints as it was the first to use a catalytic inhibitor of TOP2 rather than an agent that induces TOP2-mediated DNA damage. CAS PubMed Google Scholar. TOP2A - Wikipedia. TOP2A. DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene . Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids

top2

It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another.. Targeting DNA topoisomerase II in cancer chemotherapy - PMC. Introduction. An important reason why Top2 has held the interest of researchers studying cancer was the discovery that active anti-cancer drugs, notably etoposide and doxorubicin target Top2 1.These studies showed that most clinically active drugs that target Top2 generate enzyme mediated DNA damage 2-4.Since etoposide and doxorubicin are highly active anti-cancer agents in many different .. Regulation of topoisomerase II stability and activity by . - Springer. DNA topoisomerases II (TOP2) are peculiar enzymes (TOP2α and TOP2β) that modulate the conformation of DNA by momentarily breaking double-stranded DNA to allow another strand to pass through, and then rejoins the DNA phosphodiester backbone. TOP2α and TOP2β play vital roles in nearly all events involving DNA metabolism, including DNA transcription, replication, repair, and chromatin .. RAD54L2 counters TOP2-DNA adducts to promote genome stability

top2

To identify factors involved in TOP2 biology, we performed CRISPR-Cas9 gene inactivation screens in wild-type (WT) and tumor protein 53 (TP53) knockout (TP53 KO) human retinal pigment epithelial (RPE-1) cells using a focused dual-guide RNA library targeting 852 DNA damage response (DDR)-related genes ().In addition to identifying factors whose loss is known to cause etoposide .. Frontiers | Discovery of New Catalytic Topoisomerase II Inhibitors for .

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. Poison inhibitors of DNA topoisomerase II (TOP2) are clinically used drugs that cause cancer cell death by inducing DNA damage, which mechanism of action is also associated with serious side effects such as secondary malignancy and cardiotoxicity. In contrast, TOP2 catalytic inhibitors induce limited DNA damage, have low cytotoxicity, and are effective in suppressing cancer cell proliferation.. Topoisomerase II-Induced Chromosome Breakage and Translocation Is .. TOP2 activity is enriched at boundaries of loop domains, usually coincident with the binding of cohesin and CTCF (Canela et al., 2017).To determine how cohesin affects the distribution of TOP2 lesions, we examined mouse embryonic fibroblasts (MEFs) in which SMC3, a cohesin subunit, was depleted by CRE-mediated recombination, resulting in the disruption of nuclear architecture (Busslinger et al .. Regulation of topoisomerase II stability and activity by ubiquitination .. DNA topoisomerases II (TOP2) are peculiar enzymes (TOP2α and TOP2β) that modulate the conformation of DNA by momentarily breaking double-stranded DNA to allow another strand to pass through, and then rejoins the DNA phosphodiester backbone. TOP2α and TOP2β play vital roles in nearly all events involving DNA metabolism, including DNA .. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA . - Science. The key intermediate in the TOP2 reaction is the covalent protein-DNA TOP2 cleavage complex (TOP2cc), a protein-DNA cross-link that forms between the active-site TOP2 tyrosine and the 5′ terminus of the incised DNA duplex . TOP2 is critical for facilitating DNA processes such as replication and transcription (3-5). However, it can be .. OU womens basketball upsets Kansas State for first win vs. top-2 . - MSN. Oklahoma womens basketball live score updates vs

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. Kansas State in Big 12 game. Story by Ryan Aber, The Oklahoman

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. Coach Jennie Baranczyk and the Oklahoma Sooners (13-6, 7-1 Big 12) host the .. Nucleolar translocation of human DNA topoisomerase II by ATP . - Nature. DNA topoisomerase II (TOP2) is a nuclear protein that resolves DNA topological problems and plays critical roles in multiple nuclear processes. Human cells have two TOP2 proteins, TOP2A and TOP2B .. 2024 Senior Bowl: Michael Penix Jr., Bo Nix among top prospects, plus .

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. The stage is set for Super Bowl LVIII, which means that one game stands between the end of the NFL season and sole focus shifting to the talent acquisition portion of the offseason. Preparation .. Optimization of New Catalytic Topoisomerase II Inhibitors as an Anti .. DNA topoisomerase II (TOP2) is a drug target for many types of cancers

top2

However, clinically used TOP2 inhibitors not only kill cancer cells, but also damage normal cells, and can even give rise to other types of cancers. To discover new TOP2 inhibitors to more effectively treat cancer patients, we have applied computer-aided drug design .. Wild weather expected at AT&T Pebble Beach Pro-Am - PGA TOUR. This years AT&T Pebble Beach Pro-Am features a reimagined format as a Signature Event with 80 professionals. Each professional will compete alongside an amateur partner for the first two rounds .. 2024 Senior Bowl takeaways (Day 1): Tulane QB, Georgia WR among .. Several prospects made the most of the first day of the 2024 Senior Bowl from Mobile, Alabama. One of those players was Tulanes Michael Pratt, who is hoping to move up the food chain of .. UCLA. UCLA . @description. Quinn will not be Rivera 2.0 with Commanders - NBC Sports. Quinn will not be Rivera 2.0 with Commanders. February 1, 2024 12:35 PM. Matthew Berry reacts to the Washington Commanders reportedly bringing in Dan Quinn as the teams next head coach, explaining why the hire is "not super exciting" but could work out in the long run.. Targeting DNA topoisomerase II in cancer chemotherapy - Nature. The ability to interfere with topoisomerase II (TOP2) and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. Can recent studies lead to refined targeting of TOP2 .. College basketball rankings: Purdue holds top spot after near-upset .. Purdue has been in the top five of the AP Top 25 poll for 29 straight weeks

top2

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. 1. Simply put: few programs, and .. MOLECULAR BIOLOGY Copyright © 2022 Untangling the roles of TOP2A and .. TOP2 inhibitors impair the enzymatic activity of TOP2 by dis-rupting the noncovalent catalytic steps in the TOP2 reaction cycle leading to different biochemical and cellular consequences (Fig. 2B) (50, 53)

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. For instance, merbarone substantially decreases the catalytic activity of TOP2 by specifically blocking TOP2 cleavage of its sub-. 855636 - Gene ResultTOP2 DNA topoisomerase 2 [] - National Center for .. Remodelling Top2 binding is thus an important new means by which Snf2 enzymes promote genome stability. Reaction rates for individual steps in the DNA cleavage reaction are characterized

. Kinetic pathway of divalent ions in the DNA cleavage reaction is revealed. Sequence-preferential DNA bending is induced for the cleavage site selection by TOP2.. Rumors that Zelenskyy plans to dismiss Ukraines top commander expose .. Updated 1:33 PM PST, January 31, 2024. Rifts within Ukraines top leadership have burst into the open following swirling rumors that the countrys top military chief will be dismissed amid reported tensions with President Volodymyr Zelenskyy. The rumors that Valerii Zaluzhnyi would be sacked were denied by Zelenskyys office and the ..